In recent years, increasing evidence has pointed to the potential role of fibrinolysis in the pathogenesis of MS. Based on hypotheses describing the aggressive autoimmune responses observed in MS patients, a result of impaired between (t-PA and PA1-1) which are a key molecules in both fibrinolysis and extracellular proteolysis. The present study was done to investigate the therapeutic potential of polymerase enzyme in modulating the changes occurred between levels of Tissue- type plasminogen activator (t-PA) and its inhibitor (PAI-1) in patients with multiple sclerosis. A pilot study was carried out on a total of twenty-one patients (17 females, 4 males; aged 22-46 years) with demyelination suggestive of MS and clinically silent T2 brain lesions on magnetic resonance imaging (MRI).
NIH Funded Articles
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Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They are most commonly found in the gastrointestinal tract and respiratory system.
Feline lower urinary tract disease (FLUTD) is a supposed to a life threatening condition in cats, especially in males (Toms), when obstructive. Early diagnosis and treatment is necessary otherwise it may lead to death. Condition appears with stranguria, pollakiuria, dysuria and sometime in severe conditions hematuria and anuria may be present. Similar five cases of age ranging from 3-6 years, with common history of commercial feed and indoor placement were examined during the course of 3 month. Firstly clinical evaluation including clinical parameters and physical manipulation was done followed by laboratory tests. Complete blood count (CBC) didn’t give any significant change but urinalysis results were quite doubtful with high values of specific gravity (SP), pH, erythrocyte, bacterial and leukocyte count.
The proposed study was undertaken among 152 male and 155 female participants belonging to one population group of North India within age range 18-60 years. They were examined for extra digital flexion creases on the volar surface of all digits. Palm prints were obtained from both the right and left hand of each individual. The result showed that out of 3070 digits of 307 participants, 46 digits from 23 (16 male and 7 female) participants show the prevalence of extra digital flexion crease either on right or left palm.